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Two Agents Deliver Knockout Punches to Ewing Sarcoma

WASHINGTON — When combined with an already FDA-approved chemotherapy, a novel agent developed by researchers at Georgetown Lombardi Comprehensive Cancer Center, appears to halt the ability of Ewing sarcoma to grow and progress. The finding, in cell lines and animal models, warrants clinical investigation to see if the combination would be an effective treatment as well as a less toxic alternative to current therapy for the rare bone cancer, the researchers say. The study, published October 3 in the journal Science Signaling (Inhibition of the oncogenic fusion protein EWS-FLI1 AQ1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in…

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Transferring Lymph Nodes from One Part of the Body to Another to Treat Lymphedema

Women with Breast Cancer Get Relief from Painful and Disfiguring Side Effect of Treatment Thanks to New Procedure

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Cross-Linking Eye Procedure Stops the Progression of Vision Loss

New Office-based Treatment Uses UV Light to Strengthen Cornea, Avoids Need for Corneal Transplant

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Protein Associated with Parkinson’s Disease Linked to Human Upper GI Tract Infections

WASHINGTON  —Acute and chronic infections in a person’s upper gastrointestinal tract appear to be linked to Parkinson’s disease, say scientists at Georgetown University Medical Center and their collaborators at the National Institutes of Health and other institutions. Their study, published in the Journal of Innate Immunity, finds that alpha-Synuclein (αS), the protein implicated in Parkinson’s disease and other forms of neurodegenerative diseases, is released when an infection occurs in the upper GI tract (the esophagus, stomach and duodenum) inducing an immune response as part of the body’s innate immune system. The researchers say that these findings suggest that frequent or…

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Two Agents Deliver Knockout Punches to Ewing Sarcoma
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