Fewer Complications, Side-Effects for Esophageal Cancer Patients

Because most esophageal cancers are in close proximity to many critical organs, the need to reduce exposure to surrounding, healthy tissue is a major treatment consideration. A number of clinical and modeling studies have demonstrated that proton therapy may be safer than, and equally effective as, more conventional radiation in certain scenarios: 

Locally advanced, unresectable esophageal cancer

  • Can be applied in higher doses with less cardiac and pulmonary toxicities [1]
  • Demonstrates favorable cancer control rates using dose escalated proton therapy [2-5]

Resectable esophageal cancer with neoadjuvant therapy

  • Reduces radiation exposure to the heart, lung, and liver [4]
  • Results in lower rates of post-operative, cardiac, gastrointestinal, and wound complications as compared to conventional radiation[5]
  • Produces fewer side-effects including less nausea and adverse hematologic reactions [5]

Recurrent esophageal cancer

  • Can re-irradiate with acceptable cancer control rates and safety [6]

1. Wang, S.L., et al., Investigation of clinical and dosimetric factors associated with postoperative pulmonary complications in esophageal cancer patients treated with concurrent chemoradiotherapy followed by surgery. Int J Radiat Oncol Biol Phys, 2006. 64(3): p. 692-9.

2. Koyama, S., et al., Proton beam therapy for patients with esophageal carcinoma. Jpn J Clin Oncol, 1994. 24(3): p. 144-53.

3. Sugahara, S., et al., Clinical results of proton beam therapy for cancer of the esophagus. Int J Radiat Oncol Biol Phys, 2005. 61(1): p. 76-84.

4. Yu, J., et al., Motion-robust intensity-modulated proton therapy for distal esophageal cancer. Med Phys, 2016. 43(3): p. 1111-8.

5. Chuong, M.D., et al., Improving Outcomes for Esophageal Cancer using Proton Beam Therapy. Int J Radiat Oncol Biol Phys, 2016. 95(1): p. 488-97.

6. Fernandes, A., et al., A Prospective Study of Proton Beam Reirradiation for Esophageal Cancer. Int J Radiat Oncol Biol Phys, 2016. 95(1): p. 483-7.

For more information, please contact Cheryl Savage, Administrator, Department of Radiation Medicine

Phone: 202-444-4639

Email: [email protected]